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Bodybuilding Hormones Male Enhancement Steroids Aldactone Spironolactone

Brand Name : Pharmlab
Model Number : 98319-26-7
Certification : ISO 9001, USP, GMP
Place of Origin : China
MOQ : 10g
Price : negotiation
Payment Terms : Western Union, Money Gram, T/T, Bitcoin
Supply Ability : Mass In Stock
Delivery Time : Shipment within 24 hours, 3 to 5 days arrived
Packaging Details : Well disguised package with safe new shipping method;As requested.
Product Name : Spironolactone
CAS : 52-01-7
Appearence : White or almost white fine crystalline powder
Grade : Pharmaceutical Grade
Assay : >99%
MF : C24H32O4S
MW : 416.57
Shipping Method : EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC
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Hormones Aldactone Spironolactone Pharmaceutical Raw Materials For Male Sexual Dysfunction Treatment


Product Description
Spironolacton


Synonym: Aldactone;Antisterone;spirolactone;7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,
17-beta- carbolactone


CAS: 52-01-7


EINECS: 200-133-6


MF: C24H32O4S


MW: 416.5735


Density: 1.24g / cm3


Melting point: 198-207 ºC (dec.)


Boiling point: 597 ° C at 760 mmHg


Flash Point: 302.2 ° C


Water-soluble: practically insoluble


Vapor Pressure: 3.24E-14mmHg at 25 ° C


Specific rotation -37 ° (c = 1, CHCl3)


Spironolacton Water-soluble practically insoluble


Assay: 99%


Appearance: White or almost white fine crystalline powder


Description


Spironolactone is a potent and direct antagonist of the AR, blocking androgens like testosterone from binding to and activating the receptor. The AR antagonism of spironolactone mostly underlies its antiandrogen activity and is responsible for its therapeutic benefits in the treatment of androgen - dependent conditions like acne, hirsutism, and pattern hair loss and its usefulness in hormone therapy for transgender women. In addition, the AR antagonism of spironolactone is involved in its feminizing side effects like gynecomastia in men.


Spironolactone, similarly to other steroidal antiandrogens such as cyproterone acetate, is actually not a pure, or silent, antagonist of the AR, but rather is a weak partial agonist with the capacity for both antagonistic and agonistic effects. However, in the presence of sufficiently high levels of potent full agonists like testosterone and DHT ( the cases in which spironolactone is usually used even with regards to the " lower " relative levels present in females ), spironolactone will behave more similarly to a pure antagonist.


Applications


Androgens like testosterone and DHT play a critical role in the pathogenesis of a number of dermatological conditions including acne, seborrhea, hirsutism ( excessive facial/body hair growth in women ), and pattern hair loss ( androgenic alopecia ).


In demonstration of this, women with complete androgen insensitivity syndrome ( CAIS ) do not produce sebum or develop acne and have little to no body, pubic, or axillary hair. Moreover, men with congenital 5α-reductase type II deficiency 5α-reductase being an enzyme that greatly potentiates the androgenic effects of testosterone in the skin, have little to no acne, scanty facial hair, reduced body hair, and reportedly no incidence of male pattern hair loss.


Conversely, hyperandrogenism in women, for instance due to polycystic ovary syndrome ( PCOS ) or congenital adrenal hyperplasia ( CAH ), is commonly associated with acne and hirsutism as well as virilization ( masculinization ) in general. In accordance with the preceding, antiandrogens are highly effective in the treatment of the aforementioned androgen-dependent skin and hair conditions


By acting as an antiandrogen, as androgens can suppress both estrogen production and signaling ( e.g., in the breasts ).


Inhibition of the conversion of estradiol to estrone, resulting in an increase in the ratio of circulating estradiol to estrone. Estradiol is far more potent than estrone as an estrogen, which is comparatively almost inactive.


Enhancement of the rate of peripheral conversion of testosterone into estradiol, thus decreasing the ratio of circulating testosterone to estradiol.



Specification


Test ItemsSpecificationTest Results
DescriptionWhite or off - white crystalline powderOff - white crystalline powder
Specific rotation-56°~-60°-58.2°
IdentificationIRMatches with working standardComplies
HPLC
SolubilityFreely soluble in chloroform and in alcohol; Very slightly soluble in waterConform
Heavy metals≤10ppm<10ppm
Water≤0.3%0.22%
Residue on ignition≤0.1%0.05%
Relative materialMaximum impurities ≤0.5%0.36%
Total impurities ≤1.0%0.52%
Assay98.5~101.0%99.68%
ConclusionThe specification conform with USP.

Our Services


1. Any Inquiries will be replied within 24 hours
2. Hight quality, fashion designs reasonable &?competitive price.Fast lead time.
3. Payment:You can pay for the order via:T/T, Western Union, Money Gram



After Sale Service


1. All products will have been strictly Quality Checked in house before pecking.
2. All products will be well packed before shipping.
3. Parcel can be sent out in 24 hours after payment.Tracking number available
4 .Secure and discreet shipment.Various transportation methods for your choice.
5 .Customs pass rate ≥99%
6 .We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.


Shipping & Delivery


1. Packages are generally dispatched within approximately days after receipt of payment.
2. After the each shipping we will provide you with:
3. Will give you tracking number within 24 hours to track your package online.
4. the few pictures with your order and details.
5. About the Custom clearance,we packed in disguise ways.In our experience,the appropriate and safe delivery,there won't be problems.
6. We confirm 99% clearance,100% resending.
7. Is it the best &?safest shipping for all our repeat customers!


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